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What is D.X.3 and why should I learn about Detoxing my Liver

Writer: Healthy FoxHealthy Fox
Feb 46 min read

Updated: Feb 8

“D.X.3 is the last in our detox trio and is our take on a full spectrum liver boost. You can mobilize and bind as many toxins as you want, but if your liver isn’t up for the job then you’ll essentially get a back-up of unprocessed toxins. Your liver is also the biggest and one of the most bioactive organs in your body with many jobs. This blend of powerful botanicals and nutrients will ensure a liver thats up for the job!” 




D.X.3™


Advanced Liver Support and Antioxidant Protection

D.X.3™ is a comprehensive formula designed to help support healthy liver function and antioxidant status.* This synergistic blend includes Cordyceps sinensis, reishi mushroom, milk thistle, and other botanicals and nutrients to promote detoxification, balance inflammatory responses, and protect against oxidative stress.*


Key Features of D.X.3™

  • Supports liver detoxification: Contains milk thistle and NAC to promote normal detoxification processes.*

  • Boosts antioxidant levels: Includes reishi mushroom, NAC, and Chinese skullcap to enhance antioxidant activity in the liver and throughout the body.*

  • Promotes lipid metabolism: Cordyceps sinensis and reishi mushroom help support healthy lipid metabolism.*

  • Aids inflammatory balance: Schisandra and burdock extracts promote a healthy inflammatory response to support liver health.*

  • Clinically supported ingredients: Standardized extracts for key bioactive compounds, including silymarin, cordycepin, and polysaccharides.*


Why Choose D.X.3™?

  • Comprehensive liver support: Combines botanicals, antioxidants, and nutrients known to support detoxification, oxidative balance, and liver health.*

  • Standardized ingredients: Features clinically relevant doses of standardized extracts for consistent efficacy.*

  • Safe for long-term use: Formulated to be gentle yet effective, making it ideal for those with sensitive systems.*

  • Free from common allergens: Gluten-free, soy-free, dairy-free, and non-GMO.


Detailed Ingredient Information


Cordyceps sinensis (CordycepsPrime™)


Cordyceps sinensis is a rare Ascomycetes fungus with bioactive compounds such as cordycepin, adenosine, cordycepic acid, ergosterol, and polysaccharides. These compounds help support liver function, antioxidant status, and a balanced inflammatory response.*¹,²These benefits may be due in part to the ability of cordyceps to support antioxidant status and immune function that promotes a healthy inflammatory response.3,4


  • Lipid Metabolism and Liver Function: Cordycepin has been shown to reduce hepatocyte lipid accumulation and support autophagy through the protein kinase A/mammalian target of rapamycin pathway.⁵ In animal studies, cordycepin supplementation reduced triglyceride accumulation, hepatic fibrosis, and inflammatory markers.⁶

  • Gut Microbiota and Liver Health: Polysaccharides in cordyceps promote gut microbial diversity, which can indirectly support liver health.*⁸


Reishi Mushroom Blend (Ganoderma spp.)

Reishi mushrooms contain bioactive compounds such as triterpenes, polysaccharides, and nucleotides that support liver function and antioxidant activity.*⁹


  • Clinical Evidence: Daily supplementation with G. lucidum (225 mg) for six months improved liver enzyme markers and enhanced antioxidant capacity, reducing mild fatty liver symptoms.⁹


Milk Thistle (Silybum marianum)


Milk thistle is rich in silymarin, a flavonoid complex that supports detoxification, antioxidant status, and inflammatory balance.*¹⁵¹⁶


  • Research Evidence: Meta-analyses show silymarin supplementation reduces liver enzyme markers (ALT and AST) in patients with liver damage and nonalcoholic fatty liver disease.¹⁷¹⁸


N-Acetyl-L-Cysteine (NAC)


NAC is a precursor to glutathione, the liver’s primary antioxidant. It supports detoxification and heavy metal elimination while reducing oxidative stress.*¹⁹²¹

  • Clinical Evidence: NAC significantly improves survival rates in drug-induced liver injury cases and reduces hospital stays.²²


Chinese Skullcap (Scutellaria baicalensis)


Chinese skullcap contains flavonoids that support antioxidant activity and a balanced inflammatory response, promoting liver health and lipid metabolism.*²³²⁴


Schisandra Extract (Schisandra chinensis)

Schisandra extract supports liver function by protecting against oxidative damage and normalizing liver enzyme levels (AST and ALT).*²⁶²⁷

Burdock Extract (Arctium lappa)

Burdock extract promotes antioxidant activity and a healthy inflammatory response, which can benefit overall liver health.*²⁸²⁹

References 


  1. Ong BY, Aziz Z. Efficacy of Cordyceps sinensis as an adjunctive treatment in kidney transplant patients: A systematic review and meta-analysis. Complement Ther Med. 2017;30:84-92. doi:10.1016/j.ctim.2016.12.007.


  2. Lo HC, Hsieh C, Lin FY, Hsu TH. A systematic review of the mysterious caterpillar fungus Ophiocordyceps sinensis in Dong-ChongXiaCao (Dōng Chóng Xià Cǎo) and related bioactive ingredients. J Tradit Complement Med. 2013;3(1):16-32. doi:10.4103/2225-4110.106538.


  3. Wang Y, Wang Y, Liu D, et al. Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells. Carbohydr Polym. 2015;125:135-145. doi:10.1016/j.carbpol.2015.02.012.


  4. Lee EJ, Jang KH, Im SY, et al. Physico-chemical properties and cytotoxic potential of Cordyceps sinensis metabolites. Nat Prod Res. 2015;29(5):455-459. doi:10.1080/14786419.2014.948438.


  5. Li T, Wen L, Cheng B. Cordycepin alleviates hepatic lipid accumulation by inducing protective autophagy via the PKA/mTOR pathway. Biochem Biophys Res Commun. 2019;516(3):632-638. doi:10.1016/j.bbrc.2019.06.108.


  6. Lan T, Yu Y, Zhang J, et al. Cordycepin ameliorates nonalcoholic steatohepatitis by activation of the AMP-activated protein kinase signaling pathway. Hepatology. 2021;74(2):686-703. doi:10.1002/hep.31749.


  7. Cheng YJ, Cheng SM, Teng YH, et al. Cordyceps sinensis prevents apoptosis in mouse liver with D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure. Am J Chin Med. 2014;42(2):427-441. doi:10.1142/S0192415X14500281.


  8. Chen L, Zhang L, Wang W, et al. Polysaccharides isolated from Cordyceps sinensis contribute to the progression of NASH by modifying the gut microbiota in mice fed a high-fat diet. PLoS One. 2020;15(6):e0232972. doi:10.1371/journal.pone.0232972.


  9. Chiu HF, Fu HY, Lu YY, et al. Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. Pharm Biol. 2017;55(1):1041-1046. doi:10.1080/13880209.2017.1288750.


  10. Wu X, Zeng J, Hu J, et al. Hepatoprotective effects of aqueous extract from Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher basidiomycetes) on α-amanitin-induced liver injury in mice. Int J Med Mushrooms. 2013;15(4):383-391. doi:10.1615/intjmedmushr.v15.i4.60.


  11. Chen YS, Chen QZ, Wang ZJ, Hua C. Anti-inflammatory and hepatoprotective effects of Ganoderma lucidum polysaccharides against carbon tetrachloride-induced liver injury in Kunming mice. Pharmacology. 2019;103(3-4):143-150. doi:10.1159/000493896.


  12. Hu Z, Du R, Xiu L, et al. Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury. Cytokine. 2020;127:154917. doi:10.1016/j.cyto.2019.154917.


  13. Zhao C, Fan J, Liu Y, et al. Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis. Food Chem. 2019;271:148-156. doi:10.1016/j.foodchem.2018.07.115.


  14. Liang Z, Yuan Z, Li G, Fu F, Shan Y. Hypolipidemic, antioxidant, and antiapoptotic effects of polysaccharides extracted from Reishi mushroom, Ganoderma lucidum, in mice fed a high-fat diet. J Med Food. 2018;21(12):1218-1227. doi:10.1089/jmf.2018.4182.


  15. Abenavoli L, Izzo AA, Milić N, et al. Milk thistle (Silybum marianum): a concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytother Res. 2018;32(11):2202-2213. doi:10.1002/ptr.6171.


  16. Federico A, Dallio M, Loguercio C. Silymarin/Silybin and chronic liver disease: a marriage of many years. Molecules. 2017;22(2):191. doi:10.3390/molecules22020191.


  17. Tao L, Qu X, Zhang Y, et al. Prophylactic therapy of silymarin (Milk Thistle) on anti-tuberculosis drug-induced liver injury: a meta-analysis of randomized controlled trials. Can J Gastroenterol Hepatol. 2019;2019:3192351. doi:10.1155/2019/3192351.


  18. Zhong S, Fan Y, Yan Q, et al. The therapeutic effect of silymarin in the treatment of nonalcoholic fatty liver disease: a meta-analysis (PRISMA) of randomized control trials. Medicine (Baltimore). 2017;96(49):e9061. doi:10.1097/MD.0000000000009061.


  19. Luczak MW, Zhitkovich A. Role of direct reactivity with metals in chemoprotection by N-acetylcysteine against chromium(VI), cadmium(II), and cobalt(II). Free Radic Biol Med. 2013;65:262-269. doi:10.1016/j.freeradbiomed.2013.06.028.


  20. Mlejnek P, Dolezel P, Maier V, et al. N-acetylcysteine dual and antagonistic effect on cadmium cytotoxicity in human leukemia cells. Environ Toxicol Pharmacol. 2019;71:103213. doi:10.1016/j.etap.2019.103213.


  21. Joshi D, Kumar MD, Kumar SA, et al. Reversal of methylmercury-induced oxidative stress, lipid peroxidation, and DNA damage by the treatment of N-acetyl cysteine: a protective approach. J Environ Pathol Toxicol Oncol. 2014;33(2):167-182. doi:10.1615/jenvironpatholtoxicoloncol.2014010291.


  22. Walayat S, Shoaib H, Asghar M, et al. Role of N-acetylcysteine in non-acetaminophen-related acute liver failure: an updated meta-analysis and systematic review. Ann Gastroenterol. 2021;34(2):235-240. doi:10.20524/aog.2021.0571.


  23. Wang ZL, Wang S, Kuang Y, Hu ZM, Qiao X, Ye M. A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis. Pharm Biol. 2018;56(1):465-484. doi:10.1080/13880209.2018.1492620.


  24. Dai J, Liang K, Zhao S, et al. Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis. Proc Natl Acad Sci U S A. 2018;115(26):E5896-E5905. doi:10.1073/pnas.1801745115.


  25. Chen Q, Liu M, Yu H, et al. Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK-mediated SREBP signaling pathway. J Nat Med. 2018;72(3):655-666. doi:10.1007/s11418-018-1199-5.


  26. Yuan R, Tao X, Liang S, et al. Protective effect of acidic polysaccharide from Schisandra chinensis on acute ethanol-induced liver injury through reducing CYP2E1-dependent oxidative stress. Biomed Pharmacother. 2018;99:537-542. doi:10.1016/j.biopha.2018.01.079.


  27. Park HJ, Lee SJ, Song Y, et al. Schisandra chinensis prevents alcohol-induced fatty liver disease in rats. J Med Food. 2014;17(1):103-110. doi:10.1089/jmf.2013.2939.


  28. Zhang Y, Liao F, Guo W, et al. Schisandra chinensis exerts hepatoprotective effects against D-galactosamine/lipopolysaccharide-induced acute liver injury in mice. Food Funct. 2019;10(2):930-938. doi:10.1039/c8fo02093f.


  29. Liu P, Zhang T, Li X, et al. Protective effect of Schisandra chinensis fruit extract on liver injury induced by acetaminophen in mice. J Ethnopharmacol. 2017;209:104-110. doi:10.1016/j.jep.2017.07.014.

 
 
 

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