What is I.F.M and why should worry about Inflammation?

“I turned to this product in desperation, when rest, stretching, cold therapy or massages wouldn’t fix my back pain. I took a loading dose (6 pills) at the instruction of Dr. Michelle and all I can say is ‘woah’. Within 2-3 days it was completely gone. Although I don’t deal with chronic pain or past injuries too much, I.F.M is definitely in my emergency kit for inflammation, injuries, pain, tightness or anything that comes my way from an active lifestyle” Bryce  

I.F.M

Comprehensive Support for a Healthy Inflammatory Response

I.F.M is a synergistic combination of proteolytic enzymes, polyphenols, and botanicals designed to promote a balanced inflammatory response and support the body’s ability to degrade fibrinolytic protein compounds produced during inflammation. By aiding in oxidative stress protection and inflammatory balance, I.F.M may be helpful for managing osteoarthritis (OA), rheumatoid arthritis (RA), injury recovery, postoperative tissue repair, and other inflammatory conditions¹,².

Key Features of I.F.M

• Proteolytic Enzyme Blend: InflammEnz™ combines clinically researched enzymes, including proteases, serratiopeptidase, trypsin, and chymotrypsin. These enzymes break down inflammatory proteins like kinins and fibrin, facilitating damaged tissue removal and lymphatic drainage¹,².

• Turmeric Root Extract (Curcuma longa): Standardized to 95% curcuminoids, turmeric supports inflammatory balance by inhibiting NF-κB, IL-1, and TNF-α expression⁶,⁷.

• Boswellia Serrata Extract (as Boswellin®): Standardized to 70% boswellic acids, Boswellia has been shown to reduce 5-lipoxygenase activity, improve OA symptoms, and decrease inflammation markers such as hs-CRP¹³,¹⁵.

• Ginger Root Extract (Zingiber officinale): With 5% gingerol, ginger supports antioxidant activity and inflammatory balance in joint tissues⁹,¹⁶.

• Polyphenols: Quercetin, rutin, and resveratrol (as Veri-te™) are potent antioxidants that reduce ROS and modulate inflammatory signaling pathways¹⁸,¹⁹.

• Rosemary Leaf Extract: Standardized to 7% carnosic acid, rosemary supports antioxidant status and helps regulate pro-inflammatory cytokine expression²⁰,²¹.

Benefits

• Promotes a balanced inflammatory response¹,¹⁴

• Helps maintain healthy joint function⁶,⁹

• Supports tissue repair after injury or surgery¹,²

• Enhances antioxidant protection¹⁷,¹⁹

Ingredient Highlights

1. InflammEnz™A proprietary enzyme blend that modulates the inflammatory cascade by activating alpha‑2‑macroglobulins. These molecules bind and clear pro-inflammatory cytokines such as TNF‑α and IL‑1β³,⁴. Protease enzymes also enhance macrophage and natural killer cell activity, facilitating quicker tissue repair¹,³.

2. Turmeric (Curcuma longa):Clinical trials show turmeric alleviates joint discomfort and reduces inflammatory markers, such as hs-CRP, while promoting cartilage protection and tissue repair⁶,⁷,¹⁰.

3. Boswellia Serrata:Studies reveal Boswellia supplementation decreases inflammatory enzyme activity and improves joint stiffness in patients with knee OA¹³,¹⁵.

4. Ginger Root Extract:Ginger helps suppress pro-inflammatory signaling pathways and oxidative damage, with additional benefits for liver health and overall antioxidant status⁹,¹⁶,¹⁷.

5. Polyphenols and Rosemary Extract:Quercetin, rutin, resveratrol, and carnosic acid provide antioxidant and anti-inflammatory benefits by modulating NF-κB and COX-2 activity, supporting joint and cellular health¹⁸,¹⁹,²⁰,²¹.

References:

1. Shah D, Mital K. The role of trypsin: chymotrypsin in tissue repair. Adv Ther. 2018;35(1):31‑42. doi:10.1007/s12325‑017‑0648‑y.

2. InflammEnz™ Research. Enzymes Inc. https://www.enzymesinc.com/inflammenz‑research/. Accessed June 2, 2021.

3. pHysioProtease®. Kansas City, MO: Enzymes Inc. https://www.enzymesinc.com/physioprotease‑how‑it‑works/.

4. Brown SA, Coimbra M, Coberly DM, Chao JJ, Rohrich RJ. Oral nutritional supplementation accelerates skin wound healing: a randomized, placebo‑controlled, double‑arm, crossover study. Plast Reconstr Surg. 2004;114(1):237‑244. doi:10.1097/01.prs.0000128818.28425.52.

5. Lomax JE. The use of oral proteolytic enzymes in patients after undergoing blepharoplasty. Aesthet Surg J Open Forum. 1998;18(1):40‑41. doi:org/10.1016/S1090‑820X(98)80024‑1.

6. Amalraj A, Varma K, Jacob J, et al. A novel highly bioavailable curcumin formulation improves symptoms and diagnostic indicators in rheumatoid arthritis patients: a randomized, double‑blind, placebo‑controlled, two‑dose, three‑arm, and parallel‑group study. J Med Food. 2017;20(10):1022‑1030. doi:10.1089/jmf.2017.3930.

7. Barchitta M, Maugeri A, Favara G, et al. Nutrition and wound healing: an overview focusing on the beneficial effects of curcumin. Int J Mol Sci. 2019;20(5):1119. doi:10.3390/ijms20051119.

8. Tabrizi R, Vakili S, Akbari M, et al. The effects of curcumin‑containing supplements on biomarkers of inflammation and oxidative stress: a systematic review and meta‑analysis of randomized controlled trials. Phytother Res. 2019;33(2):253‑262. doi:10.1002/ptr.6226.

9. Ansari MY, Ahmad N, Haqqi TM. Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols. Biomed Pharmacother. 2020;129:110452. doi:10.1016/j.biopha.2020.110452.

10. Daily JW, Yang M, Park S. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: a systematic review and meta‑analysis of randomized clinical trials. J Med Food. 2016;19(8):717‑729. doi:10.1089/jmf.2016.3705.

11. Burge K, Gunasekaran A, Eckert J, Chaaban H. Curcumin and intestinal inflammatory diseases: molecular mechanisms of protection. Int J Mol Sci. 2019;20(8):1912. doi:10.3390/ijms20081912.

12. Majeed M, Nujoma Y, Badmaev V, Parkash L. Boswellin® The Anti‑Inflammatory Phytonutrient. NJ: Nutriscience Publishers, Inc. 1996.

13. Nam DE, Kim OK, Shim TJ, Kim JH, Lee J. Effect of Boswellia serrata extracts on degenerative osteoarthritis in vitro and in vivo models. J Korean Soc Food Sci Nutr. 2014;43(5):631‑640. https://www.e‑jkfn.org/journal/view.html?volume=43&number=5&spage=631.

14. Umar S, Umar K, Sarwar AH, et al. Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis. Phytomedicine. 2014;21(6):847‑856. doi:10.1016/j.phymed.2014.02.001.

15. Majeed M, Majeed S, Narayanan NK, Nagabhushanam K. A pilot, randomized, double‑blind, placebo‑controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytother Res. 2019;33(5):1457‑1468. doi:10.1002/ptr.6338.

16. de Lima RMT, Dos Reis AC, de Menezes APM, et al. Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]‑gingerol in cancer: a comprehensive review. Phytother Res. 2018;32(10):1885‑1907. doi:10.1002/ptr.6134.

17. Hamza AA, Heeba GH, Hamza S, Abdalla A, Amin A. Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/inflammation pathway. Biomed Pharmacother. 2021;134:111102. doi:10.1016/j.biopha.2020.111102.

18. Sung S, Kwon D, Um E, Kim B. Could polyphenols help in the control of rheumatoid arthritis? Molecules. 2019;24(8):1589. doi:10.3390/molecules24081589.

19. Bao TQ, Li Y, Qu C, Zheng ZG, Yang H, Li P. Antidiabetic effects and mechanisms of rosemary (Rosmarinus officinalis L.) and its phenolic components. Am J Chin Med. 2020;48(6):1353‑1368. doi:10.1142/S0192415X20500664.

20. Liu M, Zhou X, Zhou L, et al. Carnosic acid inhibits inflammation response and joint destruction on osteoclasts, fibroblast‑like synoviocytes, and collagen‑induced arthritis rats. J Cell Physiol. 2018;233(8):6291‑6303. doi:10.1002/jcp.26517.

21. Maione F, Cantone V, Pace S, et al. Anti‑inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions. Br J Pharmacol. 2017;174(11):1497‑1508. doi:10.1111/bph.13545.