top of page
HealthyFox-logo-01-1320x528.png
HF-LOGO-Name-1320x710.png

What is I.M.U.N and why is Focusing on your Immunity is important

Writer: Healthy FoxHealthy Fox
Feb 45 min read

Updated: Feb 8

“If you either have bad annual cold/flu illnesses that put you in bed for weeks, or suffer from these illnesses more than 2 times a year (or both) then I.M.U.N is the answer! Since COVID era, everyone has had a specific interest in reducing, mitigating or avoiding respiratory illness, cold or flu. With good reason, as a poor functioning immune system not only is frustrating with relentless symptoms but can actually damage your body quicker than it can repair itself. I.M.U.N’s unique herbs and nutrients have evidence to reduce length of symptoms and fine tune the immune system's function.” 





I.M.U.N™ – Natural Support for Immune Balance


I.M.U.N™ is a synergistic blend of nutrients designed to support and balance the immune response naturally. It features Tinofend®, a clinically researched extract from Tinospora cordifolia, shown to regulate key immune mediators and promote macrophage activity. Additionally, I.M.U.N™ includes quercetin, nettle leaf, and vitamin C to help maintain normal histamine levels and support immune function.


Key Benefits:

  • Supports normal histamine metabolism

  • Promotes immune system balance and response

  • Helps maintain healthy inflammatory responses


Key Ingredients:

  • Tinofend® (Guduchi Extract): Derived from Tinospora cordifolia, Tinofend® has a long history of use in traditional medicine to support immune function. It works by regulating key immune mediators and stimulating macrophages, which play a central role in immune defense.*1 Tinofend® helps modulate the activity of white blood cells, promoting balance in the immune system.*3

  • Quercetin: A powerful polyphenol found in many fruits and vegetables, quercetin supports antioxidant status and inhibits histamine release from mast cells. This helps maintain a balanced immune response, especially to environmental challenges.*6 Quercetin also supports Th1/Th2 immune balance and reduces antigen-specific IgE antibodies.*6,8,9

  • Nettle Extract: Nettle has immune-modulatory properties that support a healthy inflammatory response. It may help reduce the release of inflammatory cytokines and modulate allergic reactions, making it an ideal ingredient for managing immune health.*12

  • Vitamin C: Vitamin C is an essential nutrient that supports immune function, reduces histamine levels, and acts as a powerful antioxidant. It helps break down histamine and inhibit its production, supporting a normal immune response to allergens.*15


Supporting Immune HealthI.M.U.N™ works by combining ingredients that support the immune system through multiple pathways. Tinofend® (Guduchi) has been shown to reduce eosinophil count, which helps alleviate allergic reactions and supports a healthy inflammatory response.*3 Clinical studies have demonstrated its effectiveness in reducing symptoms of allergic rhinitis, such as sneezing, nasal discharge, and nasal obstruction.*5


Quercetin’s ability to inhibit histamine release helps balance immune responses, particularly during allergy season, while nettle extract promotes a healthy inflammatory response by inhibiting key inflammatory pathways.*12 Vitamin C provides additional support by lowering histamine levels and bolstering the body’s ability to manage immune challenges.*15


How I.M.U.N™ WorksI.M.U.N™ combines these science-backed ingredients to work together in promoting a balanced immune system. Whether you are addressing seasonal allergies or just looking to maintain healthy immune function, I.M.U.N™ offers natural, scientifically supported support.


References : 

  1. Ng AE, Boersma, P. Diagnosed allergic conditions in adults: United States, 2021. National Center for Health Statistics. 2023;460. Available at: https://www.cdc.gov/nchs/products/databriefs/db460.htm

  2. Gutowska‑Ślesik J, Samoliński B, Krzych‑Fałta E. The increase in allergic conditions based on a review of literature. Postepy Dermatol Alergol. 2023;40(1):1‑7. doi:10.5114/ada.2022.119009

  3. Abbas M, Moussa M, Akel H. Type I hypersensitivity reaction. In: StatPearls. StatPearls Publishing. Updated July 17, 2023. Accessed June 14, 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK560561/

  4. Thangam EB, Jemima EA, Singh H, et al. The role of histamine and histamine receptors in mast cell‑mediated allergy and inflammation: the hunt for new therapeutic targets. Front Immunol. 2018;9:1873. doi:10.3389/fimmu.2018.01873

  5. Mlcek J, Jurikova T, Skrovankova S, Sochor J. Quercetin and its anti‑allergic immune response. Molecules. 2016;21(5):623. doi:10.3390/molecules21050623

  6. Shaik Y, Caraffa A, Ronconi G, Lessiani G, Conti P. Impact of polyphenols on mast cells with special emphasis on the effect of quercetin and luteolin. Cent Eur J Immunol. 2018;43(4):476‑481. doi:10.5114/ceji.2018.81347

  7. Blank U, Rivera J. The ins and outs of IgE‑dependent mast‑cell exocytosis. Trends Immunol. 2004;25(5):266‑273. doi:10.1016/j.it.2004.03.005

  8. Yang CC, Hung YL, Li HJ, et al. Quercetin inhibits histamine‑induced calcium influx in human keratinocyte via histamine H4 receptors. Int Immunopharmacol. 2021;96:107620. doi:10.1016/j.intimp.2021.107620

  9. Middleton E, Jr., Drzewiecki G, Krishnarao D. Quercetin: an inhibitor of antigen‑induced human basophil histamine release. J Immunol. 1981;127(2):546‑550. doi: 10.4049/jimmunol.127.2.546

  10. Chen S, Jiang H, Wu X, Fang J. Therapeutic effects of quercetin on inflammation, obesity, and type 2 diabetes. Mediators Inflamm. 2016;2016:9340637. doi:10.1155/2016/9340637

  11. Weng Z, Zhang B, Asadi S, et al. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012;7(3):e33805. doi:10.1371/journal.pone.0033805

  12. Ziaei S, Alimohammadi‑Kamalabadi M, Hasani M, Malekahmadi M, Persad E, Heshmati J. The effect of quercetin supplementation on clinical outcomes in COVID‑19 patients: a systematic review and meta‑analysis. Food Sci Nutr. 2023;11(12):7504‑7514. doi:10.1002/fsn3.3715

  13. Dhouibi R, Affes H, Ben Salem M, et al. Screening of pharmacological uses of Urtica dioica and other benefits. Prog Biophys Mol Biol. 2020;150:67‑77. doi:10.1016/j.pbiomolbio.2019.05.008

  14. Bhusal KK, Magar SK, Thapa R, et al. Nutritional and pharmacological importance of stinging nettle (Urtica dioica L.): a review. Heliyon. 2022;8(6):e09717. doi:10.1016/j.heliyon.2022.e09717

  15. Francišković M, Gonzalez‑Pérez R, Orčić D, et al. Chemical composition and immuno‑modulatory effects of Urtica dioica L. (stinging nettle) extracts. Phytother Res. 2017;31(8):1183‑1191. doi:10.1002/ptr.5836

  16. Roschek B, Jr., Fink RC, McMichael M, Alberte RS. Nettle extract (Urtica dioica) affects key receptors and enzymes associated with allergic rhinitis. Phytother Res. 2009;23(7):920‑926. doi:10.1002/ptr.2763

  17. Jasso‑Miranda C, Herrera‑Camacho I, Flores‑Mendoza LK, et al. Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies. Infect Drug Resist. 2019;12:1833‑1852. doi:10.2147/idr.S210890

  18. Tsilioni I, Theoharides T. Luteolin is more potent than cromolyn in their ability to inhibit mediator release from cultured human mast cells. Int Arch Allergy Immunol. 2024:1‑7. doi:10.1159/000537752

  19. Huang BP, Lin CH, Chen YC, Kao SH. Anti‑inflammatory effects of Perilla frutescens leaf extract on lipopolysaccharide‑stimulated RAW264.7 cells. Mol Med Rep. 2014;10(2):1077‑1083. doi:10.3892/mmr.2014.2298

  20. Jeon IH, Kim HS, Kang HJ, et al. Anti‑inflammatory and antipruritic effects of luteolin from perilla (P. frutescens L.) leaves. Molecules. 2014;19(6):6941‑6951. doi: 10.3390/molecules19066941

  21. Kimata M, Inagaki N, Nagai H. Effects of luteolin and other flavonoids on IgE‑mediated allergic reactions. Planta Med. 2000;66(1):25‑29. doi:10.1055/s‑2000‑11107

  22. Kimata M, Shichijo M, Miura T, Serizawa I, Inagaki N, Nagai H. Effects of luteolin, quercetin and baicalein on immunoglobulin E‑mediated mediator release from human cultured mast cells. Clin Exp Allergy. 2000;30(4):501‑508. doi:10.1046/j.1365‑2222.2000.00768.x

  23. Marseglia GL, Licari A, Ciprandi G. A polycentric, randomized, double blind, parallel‑group, placebo‑controlled study on Lertal®, a multicomponent nutraceutical, as add‑on treatment in children with allergic rhinoconjunctivitis: phase I during active treatment. J Biol Regul Homeost Agents. 2019;33(2):617‑622. doi:10.1186/s13052‑019‑0678‑y

  24. Adam G, Robu S, Flutur MM, et al. Applications of Perilla frutescens extracts in clinical practice. Antioxidants (Basel). 2023;12(3):727. doi:10.3390/antiox12030727

  25. Ariano R. Efficacy of a novel food supplement in the relief of the signs and symptoms of seasonal allergic rhinitis and in the reduction of the consumption of anti‑allergic drugs. Acta Biomed. 2015;86(1):53‑58. doi:10.13140/RG.2.1.3974.8006

  26. Roxas M. The role of enzyme supplementation in digestive disorders. Altern Med Rev. 2008;13(4):307‑314

  27. Chakraborty AJ, Mitra S, Tallei TE, et al. Bromelain a potential bioactive compound: a comprehensive overview from a pharmacological perspective. Life (Basel). 2021;11(4):317. doi:10.3390/life11040317

  28. Varilla C, Marcone M, Paiva L, Baptista J. Bromelain, a group of pineapple proteolytic complex enzymes (Ananas comosus) and their possible therapeutic and clinical effects. A summary. Foods. 2021;10(10):2249. doi:10.3390/foods10102249

  29. Passali D, Passali GC, Bellussi LM, et al. Bromelain’s penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis. Acta Otorhinolaryngol Ital. 2018;38(3):225‑228. doi:10.14639/0392‑100x‑1693

  30. Hagel AF, Layritz CM, Hagel WH, et al. Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non‑allergic diseases. Naunyn Schmiedebergs Arch Pharmacol. 2013;386(9):789‑793. doi:10.1007/s00210‑013‑0880‑1

  31. Johnston CS, Solomon RE, Corte C. Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults. J Am Coll Nutr. 1996;15(6):586‑591. doi:10.1080/07315724.1996.10718634

  32. Pelletier L, Savignac M. Involvement of ion channels in allergy. Curr Opin Immunol. 2018;52:60‑67. doi:10.1016/j.coi.2018.04.00

 
 
 

Comments

bottom of page