What is T.R.M.1 and how does it help your Metabolism and Body Composition

“The first in our trio of metabolism and body composition supplements is T.R.M.1.. Your body’s ability to mobilize and metabolize fat for energy depends on the endocrine system (different glands in the body) sending the correct signals. Clients find not only a better body composition with T.R.M.1 and its trio, but will often find that their energy levels are higher throughout the day due to an improved metabolism.” Dr. Michelle 

T.R.M.1™

Support Energy, Endocrine Health, and Body Composition

T.R.M.1™ is a synergistic blend of herbs, nutrients, and bioactive compounds designed to promote energy production, endocrine function, and healthy body composition.* It supports basal metabolic rate and helps optimize energy expenditure while promoting appetite regulation and healthy blood glucose metabolism.*

T.R.M.1 is a comprehensive supplement that combines herbs and nutrients designed to support energy production and endocrine function, promoting a healthy body composition. The bioactive compounds in these ingredients also assist in supporting basal metabolic rate, potentially enhancing energy expenditure. This carefully selected blend of botanicals and nutrients is effective for promoting normal appetite regulation and supporting healthy blood glucose metabolism.

Key Features of T.R.M.1:

• 200 mg of American Ginseng (standardized to 5% ginsenosides)Supports healthy body composition and promotes thermogenesis through the activation of brown adipose tissue genes.*¹,²

• 200 mg of Garcinia Extract (standardized to 50% hydroxycitric acid)Helps support energy production and healthy body composition by inhibiting ATP citrate lyase, potentially reducing fatty acid synthesis and suppressing appetite.*³

• 300 mg of Green Tea Extract (standardized to 95% polyphenols and 45% epigallocatechin gallate (EGCg))Stimulates basal metabolic rate and supports thermogenesis and fat oxidation to promote a healthy body composition.*⁴

• 100 mg of Banaba Extract (standardized to 1% corosolic acid)Promotes antioxidant status, healthy glucose metabolism, and supports the reduction of fat accumulation.*⁵

• Chelated MineralsThese enhance bioavailability and absorption, ensuring that the active ingredients are efficiently utilized by the body.

  
  

Ingredient Highlights:

• American GinsengAmerican ginseng contains bioactive ginsenosides, such as Rb1, Rb2, and Rg1, which have been shown to promote browning of white adipose tissue by activating thermogenic genes. This helps increase mitochondrial density and supports thermogenesis. In addition, Rb1 has been shown to improve insulin sensitivity and reduce fat accumulation by regulating adipogenesis.*⁶-⁹

• Garcinia ExtractHydroxycitric acid (HCA) from Garcinia cambogia may help support healthy body composition by inhibiting the enzyme ATP citrate lyase, which is involved in the creation of acetyl-CoA, ultimately increasing carbohydrate metabolism and reducing fatty acid synthesis.*¹⁰,¹¹

• ChromiumChromium supports healthy carbohydrate and lipid metabolism, improving insulin sensitivity, and enhancing thermogenesis. A meta-analysis has shown that chromium supplementation significantly reduces body weight and body fat percentage in overweight or obese individuals.*¹⁵,¹⁶

• Green Tea ExtractThe catechins in green tea extract promote fat oxidation and thermogenesis, leading to improved body composition. Green tea also plays a role in appetite regulation by inhibiting ghrelin secretion and enhancing adiponectin levels.*¹⁷-²⁰

• Banaba ExtractBanaba extract has been shown to support glucose metabolism, inhibit adipocyte differentiation, and promote healthy body composition by activating PPAR gamma, a key regulator in adipogenesis.*²¹,²²

• Forskolin ExtractDerived from Coleus forskohlii, forskolin may promote browning of fat cells, increase lipolysis, and reduce fat cell diameter through the elevation of cAMP levels.*²³,²⁴

• VanadiumVanadium is a trace mineral that promotes normal glucose metabolism and healthy body composition by modulating energy metabolism and inhibiting adipogenesis.*²⁵

• N-Acetyl-Tyrosine and GABAThese nutrients support healthy neurotransmitter synthesis, energy balance, and may help modulate leptin action to further support appetite and metabolic function.*²⁶,²⁷

• Essential NutrientsT.R.M.1 includes vitamin C, vitamin B6, pantothenic acid, and zinc, which support cellular energy production, neurotransmitter synthesis, and antioxidant defense in the body.*

T.R.M.1 combines these powerful ingredients to promote energy, support healthy metabolism, and assist in achieving and maintaining a balanced body composition.

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Who Should Take T.R.M.1™?

T.R.M.1™ is ideal for:

• Individuals looking to support healthy weight management and body composition.*

• Those needing assistance with energy production and metabolism.*

• People seeking a natural approach to glucose regulation and appetite control.*

References 

1. Zhang L, Virgous C, Si H. Ginseng and obesity: observations and understanding in cultured cells, animals and humans. J Nutr Biochem. 2017;44:1-10. doi:10.1016/j.jnutbio.2016.11.010.

2. Zhang F, Tang S, Zhao L, et al. Stem leaves of Panax as a rich and sustainable source of less polar ginsenosides: comparison of ginsenosides from Panax ginseng, American ginseng and Panax notoginseng prepared by heating and acid treatment. J Ginseng Res. 2021;45(1):163-175. doi:10.1016/j.jgr.2020.01.003.

3. Park SJ, Park M, Sharma A, Kim K, Lee HJ. Black ginseng and ginsenoside Rb1 promote browning by inducing UCP1 expression in 3T3 L1 and primary white adipocytes. Nutrients. 2019;11(11):2747. doi:10.3390/nu11112747.

4. Mu Q, Fang X, Li X, et al. Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3 L1 adipocytes. Biochem Biophys Res Commun. 2015;466(3):530-535. doi:10.1016/j.bbrc.2015.09.064.

5. Lim S, Park J, Um JY. Ginsenoside Rb1 induces beta 3 adrenergic receptor dependent lipolysis and thermogenesis in 3T3 L1 adipocytes and db/db mice. Front Pharmacol. 2019;10:1154. doi:10.3389/fphar.2019.01154.

6. Hong Y, Lin Y, Si Q, Yang L, Dong W, Gu X. Ginsenoside Rb2 alleviates obesity by activation of brown fat and induction of browning of white fat. Front Endocrinol (Lausanne). 2019;10:153. doi:10.3389/fendo.2019.00153.

7. Liu H, Wang J, Liu M, et al. Antiobesity effects of ginsenoside Rg1 on 3T3 L1 preadipocytes and high fat diet induced obese mice mediated by AMPK. Nutrients. 2018;10(7):830. doi:10.3390/nu10070830.

8. Oh J, Lee H, Park D, Ahn J, Shin SS, Yoon M. Ginseng and its active components ginsenosides inhibit adipogenesis in 3T3 L1 cells by regulating MMP 2 and MMP 9. Evid Based Complement Alternat Med. 2012;2012:265023. doi:10.1155/2012/265023.

9. Yao L, Han Z, Zhao G, et al. Ginsenoside Rd ameliorates high fat diet induced obesity by enhancing adaptive thermogenesis in a cAMP dependent manner. Obesity (Silver Spring). 2020;28(4):783-792. doi:10.1002/oby.22761.

10. Fassina P, Scherer Adami F, Terezinha Zani V, et al. The effect of garcinia cambogia as coadjuvant in the weight loss process. Nutr Hosp. 2015;32(6):2400-2408. doi:10.3305/nh.2015.32.6.9587.

11. Semwal RB, Semwal DK, Vermaak I, Viljoen A. A comprehensive scientific overview of Garcinia cambogia. Fitoterapia. 2015;102:134-148. doi:10.1016/j.fitote.2015.02.012.

12. Han JH, Jang KW, Park MH, Myung CS. Garcinia cambogia suppresses adipogenesis in 3T3 L1 cells by inhibiting p90RSK and Stat3 activation during mitotic clonal expansion. J Cell Physiol. 2021;236(3):1822-1839. doi:10.1002/jcp.29964.

13. Han JH, Jang KW, Myung CS. Garcinia cambogia attenuates adipogenesis by affecting CEBPB and SQSTM1/p62 mediated selective autophagic degradation of KLF3 through RPS6KA1 and STAT3 suppression [published online ahead of print, Jun 8, 2021]. Autophagy. 2021;1-22. doi:10.1080/15548627.2021.1936356.

14. Payab M, Hasani Ranjbar S, Shahbal N, et al. Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta-analysis of clinical trials. Phytother Res. 2020;34(3):526-545. doi:10.1002/ptr.6547.

15. Tsang C, Taghizadeh M, Aghabagheri E, Asemi Z, Jafarnejad S. A meta-analysis of the effect of chromium supplementation on anthropometric indices of subjects with overweight or obesity. Clin Obes. 2019;9(4):e12313. doi:10.1111/cob.12313.

16. Onakpoya I, Posadzki P, Ernst E. Chromium supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trials. Obes Rev. 2013;14(6):496-507. doi:10.1111/obr.12026.

17. Türközü D, Tek NA. A minireview of effects of green tea on energy expenditure. Crit Rev Food Sci Nutr. 2017;57(2):254-258. doi:10.1080/10408398.2014.986672.

18. Bolin AP, Sousa Filho CPB, Marinovic MP, Rodrigues AC, Otton R. Polyphenol rich green tea extract induces thermogenesis in mice by a mechanism dependent on adiponectin signaling. J Nutr Biochem. 2020;78:108322. doi:10.1016/j.jnutbio.2019.108322.

19. Chen LH, Chien YW, Liang CT, Chan CH, Fan MH, Huang HY. Green tea extract induces genes related to browning of white adipose tissue and limits weight gain in high energy diet fed rat. Food Nutr Res. 2017;61(1):1347480. doi:10.1080/16546628.2017.1347480.

20. Lin Y, Shi D, Su B, et al. The effect of green tea supplementation on obesity: a systematic review and dose response meta-analysis of randomized controlled trials. Phytother Res. 2020;34(10):2459-2470. doi:10.1002/ptr.6697.

21. Miura T, Takagi S, Ishida T. Management of diabetes and its complications with banaba (Lagerstroemia speciosa L.) and corosolic acid. Evid Based Complement Alternat Med. 2012;2012:871495. doi:10.1155/2012/871495.

22. Stohs SJ, Miller H, Kaats GR. A review of the efficacy and safety of banaba (Lagerstroemia speciosa L.) and corosolic acid. Phytother Res. 2012;26(3):317-324. doi:10.1002/ptr.3664.

23. Li Y, Wang X, Wang F, et al. Identification of intracellular peptides associated with thermogenesis in human brown adipocytes. J Cell Physiol. 2019;234(5):7104-7114. doi:10.1002/jcp.27465.

24. Chen JY, Peng SY, Cheng YH, Lee IT, Yu YH. Effect of forskolin on body weight, glucose metabolism and adipocyte size of diet induced obesity in mice. Animals (Basel). 2021;11(3):645. doi:10.3390/ani11030645.

25. Ścibior A, Pietrzyk Ł, Plewa Z, Skiba A. Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi applications with a summary of further research trends. J Trace Elem Med Biol. 2020;61:126508. doi:10.1016/j.jtemb.2020.126508.

26. Cho H. Protein tyrosine phosphatase 1B (PTP1B) and obesity. Vitam Horm. 2013;91:405-424. doi:10.1016/B9780124077669.000171.

27. Xu Y, O’Brien WG 3rd, Lee CC, Myers MG Jr, Tong Q. Role of GABA release from leptin receptor expressing neurons in body weight regulation. Endocrinology. 2012;153(5):2223-2233. doi:10.1210/en.20112071.