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What is T.R.M.2 and how does it help your Fat Loss Journey?

Writer's picture: Healthy FoxHealthy Fox
Feb 46 min read

Updated: Feb 8

“People considering GLP-1 drugs for fat loss need to first try these highly effective natural solutions to avoid long term side effects. Stimulating fat burning or metabolic rate is often desired when clients live generally healthy lifestyles and diets but still can’t burn fat. Buying unvetted fat burning supplements can include many hoax products or worse, products that push your body into a stress response with excessive stimulants. The second in the trio of weight management supplements is T.R.M.2. This product, naturally and without stimulants, signals the body’s preference for fat burning via thermogenesis and the ‘browning effect’ with the use of extracted citruses and decaf green tea extract. It also has clinical trials for reduction of appetite!” Dr. Michelle 





T.R.M.2™


Support Metabolic Rate and Healthy Weight Management

T.R.M.2 is a carefully designed formula to support healthy weight management by increasing the body’s metabolic rate safely, without the stimulant-associated side effects commonly seen with other weight reduction products.* Bitter orange extract, combined with naringin, hesperidin, and green tea extract, provides thermogenic support to boost metabolism and promote fat oxidation.*

Naringin (Citrus grandis osbeck), an antioxidant-rich bioflavonoid glycoside found predominantly in grapefruit, enhances the thermogenic effects of p-synephrine (contained in Advantra Z®).¹ Naringin works in synergy with other citrus bioflavonoids to promote adiponectin expression, a protein hormone that regulates lipid and glucose metabolism.² These flavonoids also exhibit anti-adipogenic and anti-atherogenic properties, suppressing fatty acid and triglyceride synthesis while increasing fatty acid oxidation. In animal studies, naringin supplementation significantly reduced plasma lipid and cholesterol levels. Furthermore, naringin has shown hypoglycemic effects and improved insulin resistance markers, boosting insulin sensitivity. A double-blind RCT revealed that 600 mg of naringin combined with Advantra Z® resulted in a 122 kcal/day increase in basal metabolic rate (BMR), which translates to a theoretical 12.7-pound weight loss in one year.³


Green Tea Extract (Camellia sinensis) (decaffeinated, standardized to 45% EGCg) is known to stimulate thermogenesis and enhance BMR. Green tea extract works by inhibiting catechol-O-methyltransferase (COMT), an enzyme that metabolizes norepinephrine. This inhibition prolongs the half-life of adrenaline and p-synephrine, both of which stimulate the release of lipids from fat cells. Supplementation with green tea extract has been shown to significantly reduce cholesterol levels, improve insulin sensitivity, and enhance glucose absorption. Studies suggest that green tea catechins may prevent metabolic syndrome and related conditions such as obesity and hypertension.⁴,⁵ In an animal model, decaffeinated green tea extract rich in EGCg stimulated mitochondrial activity, improving energy expenditure through fatty acid oxidation, while also preventing fatty liver and improving insulin sensitivity.⁶


The GTE in T.R.M.2 is decaffeinated, making it suitable for individuals sensitive to caffeine, though caffeine users may still find it beneficial in combination with their regular intake, based on personal health status and tolerance.


Highlights of T.R.M.2:


  • Bitter Orange (Citrus aurantium L.) (as Advantra Z®)Standardized to contain 30% synephrine, bitter orange extract has been shown to enhance thermogenesis and BMR without causing adverse cardiovascular or CNS stimulation. Advantra Z® uses naturally-occurring p-synephrine, which mimics the effects of adrenaline but lacks the stimulant side effects, making it a safer alternative. This compound helps with glycogen breakdown, glucose uptake, and lipolysis, promoting fat loss and lean muscle mass while supporting sports performance and appetite suppression.⁷,⁸,⁹

  • Increased BMRThe combined effects of Advantra Z®, naringin, and citrus bioflavonoids can increase BMR by up to 17%, with EGCg further boosting and prolonging this increase.¹⁰

  • Normal Appetite SupportNaringin, Advantra Z®, and green tea extract work together to support normal appetite regulation and healthy weight management, without the anxiety or insomnia often caused by stimulant-based formulas.¹¹,¹²

  • No Stimulant Side EffectsUnlike other weight management products, T.R.M.2 does not cause anxiety, insomnia, or significant increases in heart rate or blood pressure, making it suitable for a wider range of individuals.¹³

  • Improved Insulin Sensitivity and Glucose ToleranceT.R.M.2 supports normal insulin sensitivity and glucose metabolism, helping to regulate blood sugar levels and reduce glucose absorption.⁵

  • Additional Health BenefitsIn addition to supporting weight management, T.R.M.2 offers antioxidant properties, promotes cardiovascular health, and provides support for brain function.⁶,⁵

T.R.M.2 offers a natural, effective solution to support healthy weight management, increase metabolism, and promote fat loss, without the harsh side effects associated with traditional stimulant-based formulas.

References: 


  1. Stohs, S. J., Preuss, H. G., Keith, S. C., Keith, P. L., Miller, H., & Kaats, G. R. (2011). Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. International Journal of Medical Sciences, 8(4), 295–301. https://doi.org/10.7150/ijms.8.295

  2. Stohs, S. J., Preuss, H. G., & Shara, M. (2012). A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. International Journal of Medical Sciences, 9(7), 527–538. https://doi.org/10.7150/ijms.4446

  3. Stohs, S. J., & Badmaev, V. (2016). A Review of Natural Stimulant and Non-stimulant Thermogenic Agents. Phytotherapy Research: PTR, 30(5), 732–740. https://doi.org/10.1002/ptr.5583

  4. Peixoto, J. S., Comar, J. F., Moreira, C. T., Soares, A. A., de Oliveira, A. L., Bracht, A. & Peralta, R. M. (2012). Effects of Citrus aurantium (bitter orange) fruit extracts and p-synephrine on metabolic fluxes in the rat liver. Molecules, 17, 5854-5869.

  5. De Oliveria, A. L., Comar, J. F., de Sa-Nakanishi, A. B., Peralta, R. M., Bracht, A. (2014). The action of p-synephrine on hepatic carbohydrate metabolism and respiration occurs via both Ca(2+)-mobilization and cAMP production. Molecular Cellular Biochemistry, 388, 135-147.

  6. Gougeon, R., Harrigan, K., Tremblay, J. F., Hedrei, P., Lemarche, M., & Morais, J. A. (2005). Increase in the thermic effect of food in women by adrenergic amines extracted from Citrus aurantium. Obesity Research, 13, 1187-1194.

  7. Hong, N. A., Cui, Z. G., Kang, H. K., Lee, D. H., Lee, Y. K., & Park, D. B. (2012). p-Synephrine stimulates glucose consumption via AMPK in L6 skeletal muscle cells. Biochem. Biophys. Res. Commun., 418, 720-724.

  8. Stohs S. J. (2017). Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p-Synephrine. Phytotherapy Research: PTR, 31(10), 1463–1474. https://doi.org/10.1002/ptr.5879

  9. Stohs, S. J., Preuss, H. G., & Shara, M. (2011). The Safety of Citrus aurantium (Bitter Orange) and its Primary Protoalkaloid p-Synephrine. Phytotherapy Research, 25(10), 1421–1428. DOI: 10.1002/ptr.3490

  10. Kaats, G. R., Leckie, R. B., Mrvichin, N., & Stohs, S. J. (2017). Increased eating control and energy levels associated with consumption of bitter orange (p-synephrine) extract: a randomized placebo-controlled study. Nutrition and Dietary Supplements, 9, 29-35.

  11. Shara, M., Stohs, S. J., & Mukattash, T. L. (2016). Cardiovascular Safety of Oral p-Synephrine (Bitter Orange) in Healthy Subjects: A Randomized Placebo-Controlled Cross-over Clinical Trial. Phytotherapy Research, 30(5), 842–847. DOI: 10.1002/ptr.5590

  12. Wu, Q., Li, R., Soromou, L. W., Chen, N., Yuan, X., Sun, G., Li, B., & Feng, H. (2014). p-Synephrine suppresses lipopolysaccharide-induced acute lung injury by inhibition of the NF-κB signaling pathway. Inflammation Research: Official Journal of the European Histamine Research Society ..., 63(6), 429–439. https://doi.org/10.1007/s00011-014-0715-7

  13. Salehi, B., Fokou, P., Sharifi-Rad, M., Zucca, P., Pezzani, R., Martins, N., & Sharifi-Rad, J. (2019). The Therapeutic Potential of Naringenin: A Review of Clinical Trials. Pharmaceuticals (Basel, Switzerland), 12(1), 11. https://doi.org/10.3390/ph12010011

  14. Alam, M. A., Subhan, N., Rahman, M. M., Uddin, S. J., Reza, H. M., & Sarker, S. D. (2014). Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Advances in Nutrition (Bethesda, Md.), 5(4), 404–417. https://doi.org/10.3945/an.113.005603

  15. Assini, J. M., Mulvihill, E. E., & Huff, M. W. (2013). Citrus flavonoids and lipid metabolism. Current Opinion in Lipidology, 24(1), 34–40. DOI: 10.1097/mol.0b013e32835c07fd

  16. Kapoor, M. P., Sugita, M., Fukuzawa, Y., & Okubo, T. (2017). Physiological effects of epigallocatechin-3-gallate (EGCG) on energy expenditure for prospective fat oxidation in humans: A systematic review and meta-analysis. The Journal of Nutritional Biochemistry, 43, 1–10. DOI: 10.1016/j.jnutbio.2016.10.013

  17. Hursel, R., Viechtbauer, W., Dulloo, A. G., Tremblay, A., Tappy, L., Rumpler, W., & Westerterp-Plantenga, M. S. (2011). The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obesity Reviews, 12(7). DOI: 10.1111/j.1467-789x.2011.00862.x

  18. Samavat, H., Newman, A. R., Wang, R., Yuan, J. M., Wu, A. H., & Kurzer, M. S. (2016). Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial. The American Journal of Clinical Nutrition, 104(6), 1671–1682. https://doi.org/10.3945/ajcn.116.137075

  19. Sae-tan, S., Grove, K. A., & Lambert, J. D. (2011). Weight control and prevention of metabolic syndrome by green tea. Pharmacological Research, 64(2), 146–154. https://doi.org/10.1016/j.phrs.2010.12.013

  20. Bogdanski, P., Suliburska, J., Szulinska, M., Stepien, M., Pupek-Musialik, D., & Jablecka, A. (2012). Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutrition Research, 32(6), 421–427. DOI: 10.1016/j.nutres.2012.05.007

  21. Santamarina, A. B., Carvalho-Silva, M., Gomes, L. M., Okuda, M. H., Santana, A. A., Streck, E. L., … Oyama, L. M. (2015). Decaffeinated green tea extract rich in epigallocatechin-3-gallate prevents fatty liver disease by increased activities of mitochondrial respiratory chain complexes in diet-induced obesity mice. The Journal of Nutritional Biochemistry, 26(11), 1348–1356. DOI: 10.1016/j.jnutbio.2015.07.002

  22. Katada, S., Yanagimoto, A., Matsui, Y., Hibi, M., Osaki, N., Kobayashi, S., & Katsuragi, Y. (2020). Effect of tea catechins with caffeine on energy expenditure in middle-aged men and women: a randomized, double-blind, placebo-controlled, crossover trial. European Journal of Nutrition, 59(3), 1163–1170. https://doi.org/10.1007/s00394-019-01976-9

  23. Ratamess, N. A., Bush, J. A., Kang, J., Kraemer, W. J., Stohs, S. J., Nocera, V. G., Leise, M. D., Diamond, K. B., & Faigenbaum, A. D. (2015). The effects of supplementation with P-Synephrine alone and in combination with caffeine on resistance exercise performance. Journal of the International Society of Sports Nutrition, 12, 35. https://doi.org/10.1186/s12970-015-0096-5

  24. Stuby, J., Gravestock, I., Wolfram, E., Pichierri, G., Steurer, J., & Burgstaller, J. M. (2019). Appetite suppressing and satiety-increasing bioactive phytochemicals: A systematic review. Nutrients, 11(9), 2238. https://doi.org/10.3390/nu11092238

 
 
 

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